A systematic review of the long-term effects of dental development disturbances after hematopoietic stem-cell transplantation in pediatric patients

Autores Alexandre Viana Frascino, Fábio Luiz Coracin, Paulo Sérgio da Silva Santos

Data de publicação
31/12/2014

Fonte
Clinical and Laboratorial Research in Dentistry

Volume
20

Edição
4

Páginas
252-259

Descrição
The purpose of this systematic review was to evaluate published data and to update our current knowledge about the impact on dental development of childhood hematopoietic stem-cell transplantation (HSCT), as well as the late effects of preparative regimens, for the treatment of onco-hematological malignancies. A systematic literature research was conducted to assess articles published since January 1980 until the present day that fi tted the predetermined inclusion/exclusion criteria. Data compilation was divided into qualitative and quantitative dental development disturbances. Demographic records were also gathered. First and second premolars and second molars were signifi cantly more affected in HSCT children. There was a positive correlation between age at the time of anticancer therapy administration and qualitative and quantitative dental development disturbances. The association of total body or head and neck radiation mieloablative treatments was shown to enhance the magnitude of dental development disturbances. Dental development disturbances due to childhood HSCT are commonly seen in long-term survivors. The knowledge of these alterations may help improve dental care and elevate the quality of life of these patients. Further studies are needed to understand the long-term effects of dental development disturbances in this group of patients.

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A systematic review of the long-term effects of dental development disturbances after hematopoietic stem-cell transplantation in pediatric patients
AV Frascino, FL Coracin, PS da Silva Santos - Clinical and Laboratorial Research in Dentistry, 2014

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