Impact of Pediatric Hematopoietic Stem-Cell Transplantation on Craniofacial Growth

Autores Alexandre Viana Frascino, Marcelo Fava, Maria Dulce Silveira Collassanti, Vicente Odone-Filho

Data de publicação
2020

Publicações
Clinics

Volume
75

Editora
Faculdade de Medicina/USP

Descrição
OBJECTIVES:
Brazil has rapidly developed the second-highest number of COVID-19 cases in the world. As such, proper symptom identification, including gastrointestinal manifestations, and relationship to health outcomes remains key. We aimed to assess the prevalence and impact of gastrointestinal symptoms associated with COVID-19 in a large quaternary referral center in South America.

METHODS:
This was a single-center cohort study in a COVID-19 specific hospital in São Paulo, Brazil. Consecutive adult patients with laboratory confirmed SARS-CoV-2 were included. Baseline patient history, presenting symptoms, laboratory results, and clinically relevant outcomes were recorded. Regression analyses were performed to determine significant predictors of the gastrointestinal manifestations of COVID-19 and hospitalization outcomes.

RESULTS:
Four-hundred patients with COVID-19 were included. Of these, 33.25% of patients reported ≥1 gastrointestinal symptom. Diarrhea was the most common gastrointestinal symptom (17.25%). Patients with gastrointestinal symptoms had higher rates of concomitant constitutional symptoms, notably fatigue and myalgia (p<0.05). Gastrointestinal symptoms were also more prevalent among patients on chronic immunosuppressants, ACE/ARB medications, and patient with chronic kidney disease (p<0.05). Laboratory results, length of hospitalization, ICU admission, ICU length of stay, need for mechanical ventilation, vasopressor support, and in-hospital mortality did not differ based upon gastrointestinal symptoms (p>0.05). Regression analyses showed older age [OR 1.04 (95% CI, 1.02-1.06)], male …

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Alexandre Viana Frascino, Marcelo Fava, Maria Dulce Silveira Collassanti, Vicente Odone-Filho
AV Frascino, M Fava, MDS Collassanti, V Odone-Filho - Clinics, 2020

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